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Using Tramadol to treat different types of pain

         Tramadol hydrochloride is the main active ingredient in Tramadol, which is an analgesic belonging to the class of opioids that acts on the central nervous system. It works against pain, acting on the specific nerve cells of the spinal cord and the brain. Prolonged release rate indicates that the active substances passes slowly in the blood, but remains in regular amounts active for a longer time. This makes it possible to administer Tramadol twice a day. Tramadol is used to treat acute or chronic pain of moderate to severe intensity, for example: post traumatic pain (injuries, fractures), sever neuralgia, neoplastic pain, myocardial infaction, or in diagnostic or therapeutic interventions. Tramadol has been used as pain medicine for a number of years and it has been with success. Doctors will probably keep prescribing it as it is a top class drug, FDA approved and it does wonders for the patients in need!

How to use Tramadol for pain relief

            Always use Tramadol just as recommended by the doctor. Prolongued release tablets are swallowed whole with sufficient amount of liquid regardless of meal times. The dose should be adjusted according to the intensity of the pain and the clinical response of each patient. Unless the physician has prescribed otherwise, the usual doses are: Adults and adolescents over 12 years of age have te recommended dose of 150 to 200mg of Tramadol, twice a day, depending on the severity of the disease. Generally the lowest effective dose should be chosen. Do not exceed 400mg of Tramadol except for special indications. In elderly patients up to 75 years of age without clinical manifestation of hepatic or renal failure, a dose adjustment is not required. Elimination can be prolonged in elderly patients over the age of 75 years. If you have hepatic and/or renal impairment or you are on dialysis, you should not use Tramadol. You do not have to use Tramadol longer than necessary. If the nature and the severity of the disease requires long treatment with Tramadol, you must check with your doctor on a regular basis to he can see if it is the case to discontinue or not the treatment. If you are under the impression that your Tramadol treatment is too intense or too weak, consult your physician. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double dose. In case you think you have overdosed on Tramadol, contact your physician or present yourself to the nearest emergency room immediately. In case of an overdose with Tramadol, symptoms are similar to those seen with other centrally acting analgesics (opioids). These symptoms include: myosis, vomiting, sedation, convulsions and drepress respiratory to respiratory arrest, hypotension, cardiovascular collapse, hypovolemic shock, disturbances of consciousness to coma.

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Contraindications precautions and side effects of using Tramadol

            In case you have hypersensitivity to tramadol hydrochloride or to any of the excipients of the product, avoid taking Tramadol. Avoid taking tramadol when you have: acute intoxication or acute overdose with products that have central nervous system depression (ethanol, hypnotics or other analgesics or psychotropic drugs), disorders of the state of consciousness of the unknown cause, syndrome of opioid interruption, concomitant or recent treatment (less that fourteen days) with inhibitory drugs like monoamine oxidase (MAOI), concomitant opiod treatment with agonist-antagonist action, severe respiratory failure, severe hepatic impairment, epilepsy which si refractory to treatment, pregnant or breastfeeding, under the age of fifteen. Prolonged use for several months may lead to addiction. In patients who are predisposed to addiction treatment should be performed under medical supervision. Tramadol should not be used as a substitution medicine in opioid dependent patients. Although it is an opiod agonist, Tramadol can not suppress withrdrawal syndrome. Caution is recommended in patients with epilepsy or with convulsions. Tramadol may increase the risk of seizures in patients receiving concomitant medications that lower the seizure threshold, especially selective serotonin reuptake inhibitors, antidepressants, neuroleptics, centrally acting analgesics or local anesthesics. In patients with treatment controlled epilepsy or those predisposed to convulsions, Tramadol will be given only when absolutely necessary. Intracranial hypertension, head trauma and abdominal pain require caution when administering tramadol, as it may mask important symptoms for diagnosis and clinical judgement. It is not recommended to consume alcohol during treatment. Pharmacokinetic studies have shown that concomitant or previous administration of cimetidine (enzyme inhibitor) does not cause significant interactions. Ketoconazole and erythromycin (CYP3A4 inhibitors) may inhibit the metabolism of tramadol (N-demethylation), possibly the active metabolite (o-desmethyltramadol). The clinical relevance of these interactions has not been established. Quinidine is an inhibitor of the CYP2D6 P-450 isoform, reducing the plasma concentration of the M1 metabolite and diminishing the plasma concentration of Tramadol. Fluoxetine, paroxetine and amitriptyline similarly inhibit the metabolism of Tramadol. Rare cases of toxicity when associated with Digoxin have been reported. An association with Warfarin may cause an increase in prothrombin time. Do not drive while using Tramadol because this drug may affect physical capacity and it may hinder your reflexes and abilities to operate heavy machinery. Side effects include nervous system disorders: anxiety, confusion, coordination disorders, nervousness, euphoria, insomnia, somnolence, convulsion, exceptional hallucinations and delirium. Gastrointestinal disorders: abdominal pain, anorexia, flatulence, constipation, diarrhea, nausea, vomiting, dry mouth. Musculoskeletal and connective tissue disorders: hypertonia. Skin and subcutaneous tissue disorders: rash. Vascular disorders: vasodilatation, hypertension or hypotension.

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